The A21 between the Sevenoaks Weald Interchange and Vauxhall Lane Interchange will be closed in both directions for ten days.
The closure starts at 10pm on Friday 14 February 2020 and lasts until 6am on Monday 24 February 2020.
The road is being closed so the Manor Farm subway can be rebuilt and parts of the Medway Viaduct repaired.
The work has been scheduled in one go rather than over consecutive weekends following feedback on previously planned timings.
Half term week is being used when there is less school run traffic.
Leading up to the full closure there will be overnight lane closures from Monday 10 February until Thursday 13 February between 8pm and 6am.